| Description | Saikosaponin C efficiently inhibited LPS-induced apoptotic cell death via inhibition of caspase-3 activation and caspase-3-mediated-FAK degradation. |
| Synonyms | 柴胡皂苷C, 柴胡皂苷 C |
| molecular weight | 927.12 |
| Molecular formula | C48H78O17 |
| CAS | 20736-08-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 45 mg/mL (48.54 mM) |
| References | 1. Lee TH1, Chang J2, Kim BM3. Saikosaponin C inhibits lipopolysaccharide-induced apoptosis by suppressing caspase-3 activation and subsequent degradation of focal adhesion kinase in human umbilical vein endothelial cells.Biochem Biophys Res Commun. 2014 Mar 14;445(3):615-21. 2. Yu KU1, Jang IS, Kang KH, Sung CK, Kim DH.Metabolism of saikosaponin c and naringin by human intestinal bacteria.Arch Pharm Res. 1997 Oct;20(5):420-4. 3. Shyu KG1, Tsai SC, Wang BW, Liu YC, Lee CC.Saikosaponin C induces endothelial cells growth, migration and capillary tube formation.Life Sci. 2004 Dec 31;76(7):813-26. 4. Chiang LC1, Ng LT, Liu LT, Shieh DE, Lin CC.Cytotoxicity and anti-hepatitis B virus activities of saikosaponins from Bupleurum species.Planta Med. 2003 Aug;69(8):705-9. |