| Description | (S)-Willardiine (L-willardiine) is present in the seeds of Acacia and Mimosa. (S)-Willardiine is an AMPA/kainate receptor agonist (EC50 = 44.8 μM). |
| In vitro | (S)-Willardiine produces rapidly but incompletely desensitizing responses[1]. Ca2+(1.8 mM) inhibits the currents induced by willardiine(100 μM) by 50% [2]. |
| Target activity | AMPA/kainate receptor:44.8 μM(EC50） |
| Synonyms | (-)-Willardiine, L-willardiine, Willardiine |
| molecular weight | 199.16 |
| Molecular formula | C7H9N3O4 |
| CAS | 21416-43-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: Insoluble |
| References | 1. Patneau DK, et al. Activation and desensitization of AMPA/kainate receptors by novel derivatives of willardiine. J Neurosci. 1992 Feb;12(2):595-606. 2. Fukushima T, et al. Calcium inhibits willardiine-induced responses in kainate receptor GluR6(Q)/KA-2. Neuroreport. 2001 Jan 22;12(1):163-7. 3. Gressens P, et al. The effects of AMPA receptor antagonists in models of stroke and neurodegeneration. Eur J Pharmacol. 2005 Sep 5;519(1-2):58-67. |