(S)-2-Hydroxy-3-phenylpropanoic acid-product

Description	(S)-2-Hydroxy-3-phenylpropanoic acid (L-(−)-3-Phenyllactic acid) is a chiral aromatic compound involved in phenylalanine metabolism. It is likely produced from phenylpyruvate via the action of lactate dehydrogenase. The D-form of this organic acid is typically derived from bacterial sources while the L-form is almost certainly endogenous. Levels of phenyllactate are normally very low in blood or urine. High levels of PLA in the urine or blood are often indicative of phenylketonuria (PKU) and hyperphenylalaninemia (HPA). PKU is due to lack of the enzyme phenylalanine hydroxylase (PAH) so that phenylalanine is converted not to tyrosine but to phenylpyruvic acid (a precursor of phenylacetate).
Synonyms	L-(−)-3-Phenyllactic acid, L-3-苯乳酸
molecular weight	166.17
Molecular formula	C9H10O3
CAS	20312-36-1
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year
Solubility	DMSO: 55 mg/mL (330.99 mM)
References	1. Tekewe A, et al. Development and validation of HPLC method for the resolution of drug intermediates: DL-3-Phenyllactic acid, DL-O-acetyl-3-phenyllactic acid and (+/-)-mexiletine acetamide enantiomers. Talanta. 2008 Mar 15;75(1):239-45.

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