| Description | Rubitecan (9-Nitrocamptothecin) is a DNA topoisomerase I inhibitor. It inhibits DNA topoisomerase I and increases the fraction of supercoiled DNA in a cell-free assay in a concentration-dependent manner.Rubitecan is a semisynthetic agent related to camptothecin with potent antitumor and antiviral properties. |
| Synonyms | RFS 2000, 鲁比特康, 9-Nitrocamptothecin |
| molecular weight | 393.35 |
| Molecular formula | C20H15N3O6 |
| CAS | 91421-42-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 125 mg/mL (317.78 mM) |
| References | 1. Sands H , Mishra A , Stoeckler J D , et al. Preclinical activity of an i.v. formulation of rubitecan in IDD-P? against human solid tumor xenografts[J]. Anti-Cancer Drugs, 2002, 13(9):965-975. 2. Giovanella B C , Stehlin J S , Hinz H R , et al. Preclinical evaluation of the anticancer activity and toxicity of 9-nitro-20(S)-camptothecin (Rubitecan)[J]. International Journal of Oncology, 2002, 20(1):81-88. |