| Description | Rhapontigenin (Protigenin) is a mechanism-based, selective inactivator of cytochrome P450 1A1 (IC50: 400 nM), an aryl hydrocarbon hydroxylase which activates polycyclic aromatic hydrocarbons that act as procarcinogens. Rhapontigenin is a natural analog of resveratrol with antioxidant and anti-cancer activity. At higher concentrations, rhapontigenin inhibits the proliferation of HL-60R and HepG2 cancer cell lines (IC50: 48 μM). |
| Target activity | HL-60R:48 μM, HepG2 cells:48 μM, CYP1A1:400 nM |
| Synonyms | 丹叶大黄素, Protigenin |
| molecular weight | 258.27 |
| Molecular formula | C15H14O4 |
| CAS | 500-65-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble DMSO: 46 mg/mL(178.1 mM) |
| References | 1. Jo SP1, Kim JK2, Lim YH1. Antihyperlipidemic effects of rhapontin and rhapontigenin from rheum undulatum in rats fed a high-cholesterol diet.Planta Med. 2014 Aug;80(13):1067-71. 2. Kim N1, Kim JK, Hwang D, Lim YH.The possible mechanism of rhapontigenin influencing antifungal activity on Candida albicans.Med Mycol. 2013 Jan;51(1):45-52. 3. Kim JS1, Kang CG, Kim SH, Lee EO. Rhapontigenin suppresses cell migration and invasion by inhibiting the PI3K-dependent Rac1 signaling pathway in MDA-MB-231 human breast cancer cells.J Nat Prod. 2014 May 23;77(5):1135-9. |