| Description | (Rac)-Idroxioleic acid (2-Hydroxyoleic acid) is a fatty acid amide hydrolase inhibitor with anti-tumor effect. It binds to the plasma membrane and alters lipid organization. |
| In vitro | Minerval (25-50 μM; 72 hours) causes a marked and concentration-dependent increase in the proteolytic cleavage of PARP, a molecular marker of apoptosis. Minerval (25-75 μM; 72 hours) impairs Jurkat cell growth in a time- and concentration-dependent manner (IC50: 40 μM)[1]. |
| In vivo | In nude mice infected with Jurkat cells, Minerval significantly inhibits tumour growth[1]. |
| Target activity | Jurkat cells:40 μM |
| Synonyms | 2-Hydroxyoleic acid, 2-OHOA, 2-羟基乳清酸, Minerval |
| molecular weight | 298.46 |
| Molecular formula | C18H34O3 |
| CAS | 56472-29-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (167.52 mM) |
| References | 1. Llado V, et al. Minerval induces apoptosis in Jurkat and other cancer cells. J Cell Mol Med. 2010 Mar;14(3):659-70. |