| Description | Quercetin Dihydrate (Sophoretin) is a polyphenolic flavonoid that was found in a wide variety of plant-based foods, such as apples, onions, berries, and red wine. It is used for their nervous system and anticancer effects. |
| In vitro | Quercetin, a polyphenolic flavonoid found in a wide variety of plant-based foods, such as apples, onions, berries, and red wine, is utilized in many different cultures for their nervous system and anticancer effects. The pharmacological activities of quercetin that modulate antioxidation/oxidation/kinase-signaling pathways might be differentially elicited in neurons compared with malignant cells, ultimately promoting cell survival or death in a cell type- and metabolism-specific manner. Whereas the broad antioxidation and anti-inflammatory activities of quercetin are important for neuronal survival, the oxidative, kinase- and cell cycle-inhibitory, apoptosis-inducing effects of quercetin are essential for its anticancer effects. [1] |
| In vivo | LD50: Mice 159 mg/kg (i.g.) [2] |
| Target activity | PI3Kγ:2.4 μM (IC50), PI3Kβ:5.4 μM (IC50), PI3Kδ:3.0 μM (IC50) |
| Synonyms | 槲皮素, Sophoretin |
| molecular weight | 338.27 |
| Molecular formula | C15H10O7·2H2O |
| CAS | 6151-25-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: < 1 mg/mL (insoluble or slightly soluble) Ethanol: 15 mg/mL(44.3 mM) DMSO: 45 mg/mL (133.03 mM) |
| References | 1. Dajas F, J Ethnopharmacol, 2012, 143(2), 383-396. 2. Sing SE, et al. Int J Environ Res Public Health. 2011 Jul;8(7):2828-2853. |