| Description | Pyridoxylamine (pyridoxamine) is an inhibitor of advanced glycation end production (AGEs) and lipoxidation end products (ALEs). |
| In vitro | 吡哆醇胺（PM）是B6维生素素家族中的一员，是一种强效的活性醛类清除剂，它能够抑制导致晚期糖基化反应生成AGE的过程[1]。 |
| In vivo | 在STZ诱导的糖尿病大鼠中，Pyridoxylamine抑制了CML和CEL的形成以及皮肤胶原蛋白的交联，从而有效阻止了肾病的发展。Pyridoxamine似乎不通过抗氧化作用发挥效果，因为它并不抑制脂质过氧化。然而，它能够防止脂质过氧化产物对蛋白质的修饰，并抑制了在Zucker大鼠体内丙二醛和4-羟基壬烯醛与蛋白质形成加合物的过程[1]。 |
| Synonyms | pyridoxamine, 吡多胺 |
| molecular weight | 168.19 |
| Molecular formula | C8H12N2O2 |
| CAS | 85-87-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 31.25 mg/mL (185.80 mM), Sonication is recommended. H2O: 6.25 mg/mL (37.16 mM), Sonication is recommended. |
| References | 1. Stitt A, et al. The AGE inhibitor pyridoxamine inhibits development of retinopathy in experimental diabetes. Diabetes. 2002 Sep;51(9):2826-32. |