| Description | Purpurin (Verantin) was a reversible and competitive inhibitor of MAO-A with a Ki value of 0.422μM. it exhibits anti-angiogenic, antifungal, antibiotic, and antioxidative activities. |
| In vitro | Purpurin was a reversible and competitive inhibitor of MAO-A with a Ki value of 0.422μM.?A comparison of their chemical structures suggested the 4-hydroxy group of purpurin might play an important role in its inhibition of MAO-A.?Purpurin is a potent, selective, reversible inhibitor of MAO-A, and that it be considered a new potential lead compound for development of novel reversible inhibitors of MAO-A (RIMAs). |
| Target activity | MAO-A:2.50μM(ki) |
| Synonyms | 吡啉, 1,2,4-Trihydroxyanthraquinone, Hydroxylizaric acid, Verantin |
| molecular weight | 256.21 |
| Molecular formula | C14H8O5 |
| CAS | 81-54-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 18.33 mg/mL (71.56 mM) |
| References | 1. Lee H W , Ryu H W , Kang M G , et al. Selective inhibition of monoamine oxidase A by purpurin, an anthraquinone[J]. Bioorganic & Medicinal Chemistry Letters, 2017, 27(5):1136-1140. |