| Description | Pterosin B is an salt-inducible kinase 3 (Sik3) signaling inhibitor. Pterosin B prevents chondrocyte hypertrophy and osteoarthritis by inhibiting Sik3. |
| molecular weight | 218.29 |
| Molecular formula | C14H18O2 |
| CAS | 34175-96-7 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 250 mg/mL (1145.27 mM), Sonication is recommended. |
| References | 1. Hannah R.Dexter, et al. A concise stereoselective synthesis of pterosin B. Tetrahedron Letters, Volume 59, Issue 49, 5 December 2018, Pages 4323-4325. 2. Yahara Y, et al. Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3. Nat Commun. 2016 Mar 24;7:10959. |