| Description | Pterine-6-carboxylic acid (6-Carboxypterin) is a photodegradation product of folic acid, which can be used as a photosensitive agent to study the molecular mechanism of UVA breaking DNA structure. |
| In vitro | Pterin-6-carboxylic acid通过电子转移特异性地诱导DNA在连续的G残基上发生光氧化[1]。Pterin-6-carboxylic acid与磷酸二酯酶5的活性位点结合，其结合能量值为-7.1，与植物中发现的其他化合物相比，结合距离分别为2.05Å和2.23Å。通过计算机模拟研究，假设Pterin-6-carboxylic acid可以作为PDE5蛋白的抑制剂，可能成为治疗勃起功能障碍的潜在药物候选物[2]。 |
| Synonyms | 6-Carboxypterin |
| molecular weight | 207.15 |
| Molecular formula | C7H5N5O3 |
| CAS | 948-60-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: Slightly soluble |
| References | 1. Hirakawa K, et al. Sequence-specific DNA damage induced by ultraviolet A-irradiated folic acid via its photolysis product. Arch Biochem Biophys. 2003 Feb 15;410(2):261-8. 2. Iheanyichukwu, Wopara, et al. Inhibition of Phosphodiesterase 5 Enzyme by Pterine- 6 Carboxylic Acid from Baphia nitida –Related to Erectile Dysfunction: Computational Kinetic. European journal of medicinal plants (2020): 49-55. |