| Description | Przewaquinone A has antitumor activity. |
| In vitro | Column chromatography and bioassay-guided fractionation methods were carried out to yield neo-Przewaquinone A, which was identified by spectral analysis. The EC50 of neo-Przewaquinone A on M. aeruginosa were 4.68 mg L(-1). In addition, neo-Przewaquinone A showed relatively higher security on Chlorella pyrenoidosa and Scenedesmus obliquus, with the EC50 values of 14.78 and 10.37 mg L(-1), respectively. For the potential inhibition mechanisms, neo-Przewaquinone A caused M. aeruginosa cells morphologic damage or lysis, increased malondialdehyde content and decreased the soluble protein content, total antioxidant and superoxide dismutase activity, and significantly inhibited three photosynthesis-related genes (psaB, psbD, and rbcL). |
| Synonyms | 紫丹参素 A |
| molecular weight | 310.34 |
| Molecular formula | C19H18O4 |
| CAS | 76843-23-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Algicidal activity of Salvia miltiorrhiza Bung on Microcystis aeruginosa--towards identification of algicidal substance and determination of inhibition mechanism.Chemosphere. 2013 Oct;93(6):997-1004. |