| Description | Procyanidin B2 (Proanthocyanidin B2) has vascular protective, anti-diabetic nephropathy, anti-cancer, anti-inflammatory, and antioxidant activities. Procyanidin B2 inhibited NLRP3 inflammasome activation via suppression of AP-1 pathway. |
| In vitro | Procyanidin B2 通过与 H2O2 和金属离子的相互作用, 表现出抗氧化和促氧化的特性[1]。 |
| In vivo | 肉桂中的Procyanidin B2抑制了糖尿病大鼠肾脏中AGEs的积累，并改善了AGEs介导的DN[2]的病理过程。 |
| Animal experiments | Streptozotocin-induced diabetic rats were fed with either 3% cinnamon or 0.002% Procyanidin B2(PCB2)-fraction in diet for 12weeks. Biochemical analysis of blood and urine was performed at the end of experiment. Evaluation of glomerular markers that serve as indicators of renal function was done by immunohistochemistry, immunoblotting and qRT-PCR. Supplementation of diabetic rats with cinnamon and PCB2-fraction prevented glycation mediated RBC-IgG cross-links and HbA1c accumulation in diabetes rats. Cinnamon and PCB2-fraction also inhibited the accumulation of N-carboxy methyl lysine (CML), a prominent AGE in diabetic kidney[2]. |
| Synonyms | 原花青素 B2, Proanthocyanidin B2 |
| molecular weight | 578.52 |
| Molecular formula | C30H26O12 |
| CAS | 29106-49-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (86.43 mM) |
| References | 1. Sakano K , Mizutani M , Murata M , et al. Procyanidin B2 has anti- and pro-oxidant effects on metal-mediated DNA damage[J]. Free Radical Biology & Medicine, 2005, 39(8):1041-1049. 2. Muthenna P , Raghu G , Kumar P A , et al. Effect of cinnamon and its procyanidin-B2 enriched fraction on diabetic nephropathy in rats[J]. Chemico-Biological Interactions, 2014, 222:68-76. |