| Description | Polyporenic acid C shows inhibitory activity against human collagenase. |
| In vitro | Polyporenic acid C (PPAC) significantly reduced cell proliferation via induction of apoptosis as evidenced by sub-G1 analysis, annexin V-FITC staining, and increase in cleavage of procaspase-8, -3, and poly(ADP-ribose)-polymerase (PARP). However, unlike our previously reported lanostane-type triterpenoid, pachymic acid, treatment of cells with PPAC was not accompanied by disruption of mitochondrial membrane potential and increase in cleavage of procaspase-9. Further, PPC-induced apoptosis was inhibited by caspase-8 and pan-caspase inhibitors but not by a caspase-9 inhibitor. |
| Synonyms | 猪苓酸C, 聚孔酸C |
| molecular weight | 482.69 |
| Molecular formula | C31H46O4 |
| CAS | 465-18-9 |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 60 mg/mL (124.3 mM), Sonication and heating to 60℃ are recommended. |
| References | 1. Polyporenic acid C induces caspase-8-mediated apoptosis in human lung cancer A549 cells.Mol Carcinog. 2009 Jun;48(6):498-507. |