| Description | Piperlonguminine is an alkaloid amide isolated from the Piper species. Piperlonguminine shows anti-inflammatory, antitumor, neuroprotective, anti-platelet, anti-melanogenic, antifungal and antibacterial activities.Piperlonguminine is an inhibitor of Akt/mTOR signalling. It acts by promoting autophagy and mediating cancer cell death. |
| In vitro | 从荜茇（Piper longum）中提取的Piperlonguminine，被发现能抑制被alpha-梅拉诺细胞刺激素(alpha-MSH)、3-异丁基-1-甲基黄嘌呤或原卟啉IX刺激的黑色素瘤B16细胞中的黑色素生成，表现出比曲酸更强的脱色效果。然而，Piperlonguminine对由1-油酰基-2-乙酰基-sn-甘油三酯引起的黑色素生成过程及蛋白激酶C介导的黑色素生成过程均无影响。令人惊讶的是，Piperlonguminine并未抑制黑色素瘤B16细胞的无细胞酪氨酸酶的催化活性，而是抑制了酪氨酸酶mRNA的表达。这一效果归因于Piperlonguminine对alpha-MSH诱导的通过cAMP到cAMP响应元件结合蛋白的信号传导的抑制作用，进而调节微眼相关转录因子的表达，该转录因子是酪氨酸酶启动子的关键激活剂。这项研究表明，Piperlonguminine是一种效能高的脱色剂，具有新颖的作用机制。 |
| molecular weight | 273.33 |
| Molecular formula | C16H19NO3 |
| CAS | 5950-12-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 27.5 mg/mL (100.61 mM), Sonication is recommended. |
| References | 1. Inhibitory effect of piperlonguminine on melanin production in melanoma B16 cell line by downregulation of tyrosinase expression.Pigment Cell Res. 2006 Feb;19(1):90-8. |