| Description | Pinostrobin chalcone, a chalcone analog isolated from the leguminous plant, Mucuna pruriens, exhibits anticancer activity with an IC50 value of 20.42±2.23 μg/mL against MDA-MB-231 and 22.51±0.42 μg/mL against the HT-29 colon cancer cell line. |
| In vitro | Pinostrobin chalcone（30 μM；3T3-L1细胞）作为一种抑制甘油三酯积累的化合物，其效果超过了阳性对照药物berberine。基因表达研究显示，在3T3-L1细胞中处理Pinostrobin chalcone可降低CCAAT/增强子结合蛋白α±和过氧化物酶体增殖物激活受体γ2在成脂过程中的表达水平，同时不影响细胞活力。此外，使用Pinostrobin chalcone处理3T3-L1细胞能减少固醇调节元件结合蛋白1c和多种脂肪生成酶，包括脂肪酸合酶和硬脂酰CoA去饱和酶-1的mRNAs表达水平。[1] |
| Synonyms | 球松素查尔酮, 2',3'-二羟基-4'-甲氧基查耳酮 |
| molecular weight | 270.28 |
| Molecular formula | C16H14O4 |
| CAS | 18956-15-5 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 90.0 mg/mL (333.0 mM), Sonication is recommended. |
| References | 1. Oikawa N, et al. Inhibitory effects of compounds isolated from the dried branches and leaves of murta (Myrceugenia euosma) on lipid accumulation in 3T3-L1 cells. J Nat Med. 2016;70(3):502-509. 2. Mohammed I, et al. Isolation of cardamonin, pinostrobin chalcone from the rhizomes of Boesenbergia rotunda (L.) Mansf. and their cytotoxic effects on H-29 and MDA-MB-231 cancer cell lines. The Natural Products Journal. 2019;9(4):341-348. |