| Description | Picrotin is an inhibitor of glycine receptors. Picrotin blocks α2 GlyR, α1 GlyR, and α3 GlyR and can be used in studies about neurotransmission. |
| In vitro | Picrotin 对 α2 GlyRs 显示出敏感性，其 IC50 值为 13.1 μM[1]。 |
| molecular weight | 310.3 |
| Molecular formula | C15H18O7 |
| CAS | 21416-53-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 90.0 mg/mL (290.0 mM), Sonication is recommended. |
| References | 1. Li P, et al. Gating effects on picrotin block of glycine receptors. Neuroreport. 2012 Dec 5;23(17):1017-20. 2. Yang Z, et al. A proposed structural basis for picrotoxinin and picrotin binding in the glycine receptor pore. J Neurochem. 2007 Oct;103(2):580-9. |