| Description | Phenylephrine ((R)-(-)-Phenylephrine) is a selective α1-adrenoceptor agonist ( pKi: 5.86, 4.87 and 4.70 for α1D, α1B, and α1A receptors respectively). |
| In vitro | Phenylephrine促进心脏成纤维细胞的增殖。Phenylephrine激活CaN并引起NFAT3的核内转移。这表明Ca(2+)/CaN/NFAT途径介导了Phenylephrine引起的心脏成纤维细胞增殖，此途径可能是心脏纤维化治疗的潜在靶点[1][2][3]。 |
| In vivo | Phenylephrine could enhance the alveolar fluid clearance in high tidal volume-ventilated rats and accelerate the absorption of pulmonary edema. Perfusion of hearts with Phenylephrine (100 μM) induces a rapid (maximal at 10 min) 12-fold activation of two p38-MAPK isoforms. α1-adrenoceptor agonists such as Phenylephrine increase the contractility of the heart. Phenylephrine also activates SAPKs/JNKs in neonatal ventricular myocytes [4][5]. |
| Target activity | α1B-adrenoceptor:4.87 (pKi), α1A-adrenoceptor:4.70 (pKi), α1D-adrenoceptor:5.86 (pKi) |
| Synonyms | 去氧肾上腺素, L-Phenylephrine, 去氧肾上腺素碱, (R)-(-)-Phenylephrine |
| molecular weight | 167.21 |
| Molecular formula | C9H13NO2 |
| CAS | 59-42-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 100 mg/mL (598.05 mM), Sonication is recommended. H2O: 5 mg/mL (29.90 mM), Sonication is recommended. |
| References | 1. Ford AP, et al. Pharmacological pleiotropism of the human recombinant alpha1A-adrenoceptor: implications foralpha1-adrenoceptor classification. Br J Pharmacol. 1997 Jul;121(6):1127-35. 2. Minneman KP, et al. Selectivity of agonists for cloned alpha 1-adrenergic receptor subtypes. Mol Pharmacol. 1994 Nov;46(5):929-36. 3. Wang J, et al. Phenylephrine promotes cardiac fibroblast proliferation through calcineurin-NFAT pathway. Front Biosci (Landmark Ed). 2016 Jan 1;21:502-13. 4. Lazou A, et al. Activation of mitogen-activated protein kinases (p38-MAPKs, SAPKs/JNKs and ERKs) by the G-protein-coupled receptor agonist phenylephrine in the perfused rat heart. Biochem J. 1998 Jun 1;332 ( Pt 2):459-65. 5. Li NJ, et al. Effect of phenylephrine on alveolar fluid clearance in ventilator-induced lung injury. Chin Med Sci J. 2013 Mar;28(1):1-6. 6. Chen F, Xu Y, Wang J, et al. Relaxation Effect of Patchouli Alcohol in Rat Corpus Cavernous and Its Underlying Mechanisms[J]. Evidence-Based Complementary and Alternative Medicine. 2020, 2020. |