| Description | Phenylephrine hydrochloride (NCI-c55641) is a selective agonist of the α1-adrenergic receptor. |
| In vivo | Phenylephrine可使心肌细胞免受血清剥夺和缺氧处理。Phenylephrine可让PKC-epsilon发生快速易位（EC 50= 0.9 mM）,但可溶性分数损失的比例小于ET-1。Phenylephrine防止Bcl-X和Bcl-2的mRNA/蛋白质下调和诱导肥大性生长。在pCa 7时,Phenylephrine剂量依赖性引起高渗透性细胞的收缩力增加,加入phentolamine后该过程可逆。用磷脂酰肌醇3-激酶(PI 3-激酶)抑制剂wortmannin对Phenylephrine介导的保护进行了抑制,并通过caspase-9肽抑制剂LEHD-fmk进行了模拟。 Phenylephrine刺激磷酸肌醇水解,细胞生长,和心脏肥大有关几个基因[例如,心房利钠因子]的表达。Phenylephrin需要IP3和PI-3K/Akt依赖性钙离子信号的刺激才能诱导NOi的释放。Phenylephrine也通过IP3依赖的信号增加了地方,肌膜SR钙离子的释放。Phenylephrine对NOi释放的诱导作用被1 mM prazocin, 10 mM W-7, 10 mM L-NIO, 10 mM LY294002, 2 mM H-89, 5 mM thapsigargin, 10 mM ryanodine, 2 mM 2-APB or 10 mM xestospongin C抑制。1 μM Phenylephrine明显增强HGF诱导的肝细胞DNA合成和细胞增殖。 1 mM Phenylephrine可逆增加I（Ca,L）（51.3％; N=40）和转移-10 mV的激活电压的峰值I（Ca,L）。 |
| Synonyms | NCI-c55641, Phenylephrine HCl, 盐酸去氧肾上腺素, (R)-(-)-Phenylephrine hydrochloride |
| molecular weight | 203.67 |
| Molecular formula | C9H14ClNO2 |
| CAS | 61-76-7 |
| Storage | keep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 20.4 mg/mL (100 mM) H2O: 20.4 mg/mL (100 mM) |
| References | 1. Clerk A, et al. J Biol Chem,1994, 269(52), 32848-32857. 2. Collins EM, et al. Am J Physiol,1992, 262(3 Pt 2), H754-H762. 3. Zhu H, et al. Cell Death Differ,2000, 7(9), 773-784. 4. McDonough PM, et al. Am J Physiol,1993, 264(2 Pt 2), H625-H630. 5. Kimura M, et al. J Pharmacol Exp Ther,1997, 282(3), 1146-1154. 6. Wang J, et al. Phenylephrine promotes cardiac fibroblast proliferation through calcineurin-NFAT pathway. Front Biosci (Landmark Ed). 2016 Jan 1;21:502-13. |