| Description | Phellopterin is a partial agonist of the central benzodiazepine receptors in vitro. Phellopterin shows a cytotoxic effect on RAW264.7 cell at the concentration from 40 to 400 μM. Phellopterin reduce TNF-alpha-induced VCAM-1 expression through regulation of the Akt and PKC pathway, which contributes to inhibit the adhesion of monocytes to endothelium. |
| molecular weight | 300.31 |
| Molecular formula | C17H16O5 |
| CAS | 2543-94-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (166.49 mM) Chloroform: Soluble |
| References | 1. Zhao A H, et al. Biotransformation products of phellopterin by rat liver microsomes and the inhibition on NO production in LPS-activated RAW264.7 cells[J]. Journal of Asian Natural Products Research, 2012, 14(10):956-965. 2. Nizamutdinova I T, et al. Hesperidin, hesperidin methyl chalone and phellopterin from Poncirus trifoliata (Rutaceae) differentially regulate the expression of adhesion molecules in tumor necrosis factor-α-stimulated human umbilical vein endothelial cells[J]. International Immunopharmacology, 2008, 8(5):670-678. 3. Dekermendjian K, et al. Characterization of the furanocoumarin phellopterin as a rat brain benzodiazepine receptor partial agonist in vitro[J]. Neuroscience Letters, 1996, 219(3):151-154. |