| Description | Phellamurin inhibits intestinal P-glycoprotein in a dose-dependent manner, there is a serious interaction occurred between Phellamurin with cyclosporin, to ensure the efficacy of cyclosporin, we suggest that the coadministration of Phellamurin or Phellodendron wilsonii with cyclosporin should be avoided. |
| In vitro | 向U2OS和Saos-2细胞中施用0-10μg/mL Phellamurin，持续48小时，可以剂量依赖性地抑制细胞活性，促进U2OS和Saos-2细胞的凋亡，并且剂量依赖性地降低U2OS和Saos-2细胞中p-PI3K/PI3K、p-AKT/AKT及p-mTOR/mTOR的比值[1]。 |
| In vivo | 在雌性BALB/c裸鼠中，每日通过腹腔注射50毫克/千克 Phellamurin 连续21天，能有效抑制体内骨肉瘤肿瘤的增长。Phellamurin处理后的异种移植鼠中，p-PI3K/PI3K、p-AKT/AKT和p-mTOR/mTOR的比率均有所下降[1]。 |
| molecular weight | 518.51 |
| Molecular formula | C26H30O11 |
| CAS | 52589-11-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 55 mg/ml (106.07 mM) |
| References | 1. Hongzhi Zhang, et al. Anti-tumor Efficacy of Phellamurin in Osteosarcoma Cells:Involvement of the PI3K/AKT/mTOR Pathway. Eur J Pharmacol. 2019 Sep 5;858:172477. |