| Description | Penicillic acid, a polyketide mycotoxin, synthesized by various species of Aspergillus and Penicillium, acts as an inhibitor of Fas ligand-induced apoptosis by impeding self-processing of caspase-8. Additionally, in vitro studies have shown that Penicillic acid displays cytotoxic properties in rat alveolar macrophages. |
| molecular weight | 170.16 |
| Molecular formula | C8H10O4 |
| CAS | 90-65-3 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Sorenson WG, et al. Toxicity of penicillic acid for rat alveolar macrophages in vitro. Environ Res. 1986 Dec;41(2):505-13. 2. Bando M, et al. The mycotoxin penicillic acid inhibits Fas ligand-induced apoptosis by blocking self-processing of caspase-8 in death-inducing signaling complex. J Biol Chem. 2003 Feb 21;278(8):5786-93. |