| Description | Parishin C is a phenolic glycoside and a major component of G. elata, have antioxidant property |
| In vivo | In vivo, parishin C (20 mg/kg) prevents Aβ42-induced inhibition of long-term potentiation (LTP) in rats. Parishin is an agonist of the serotonin (5-HT) receptor subtype 5-HT1A (Ki = 1.54 nM; EC50 = 34 nM for [35S]GTPγS binding) that reverses phencyclidine-induced increases in immobility time in the forced swim test, phencyclidine-induced decreases in interaction time in the social interaction test, and phencyclidine-induced impairments in visual recognition of a novel object in mice[1]. |
| Synonyms | 巴利森苷 C, 巴利森苷C |
| molecular weight | 728.65 |
| Molecular formula | C32H40O19 |
| CAS | 174972-80-6 |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 7.29 mg/mL (10 mM) |
| References | 1. Shin E J , Whang W K , Kim S , et al. Parishin C Attenuates Phencyclidine-Induced Schizophrenia-Like Psychosis in Mice: Involvements of 5-HT1A Receptor[J]. Journal of Pharmacological Sciences, 2010, 113(4):404-408. 2. Kim DW, Lee WJ, Asmelash Gebru Y,et al.Comparison of Bioactive Compounds and Antioxidant Activities of Maclura tricuspidata Fruit Extracts at Different Maturity Stages[J].Molecules. 2019 Feb 4;24(3). pii: E567. |