| Description | Paeonol (Peonol) is an active extraction from Paeonia suffruticosa. Paeonol inhibits MAO-A and MAO-B with IC50 of 54.6 μM and 42.5 μM, respectively. |
| In vitro | Paeonol在小鼠体内,LD50:608-899 mg/kg(i.p.) |
| In vivo | 丹皮酚通过调节组胺和TNF-α抑制过敏反应。 |
| Target activity | MAO-B:42.5 μM, MAO-A:54.6 μM |
| Synonyms | 丹皮酚, Peonol |
| molecular weight | 166.17 |
| Molecular formula | C9H10O3 |
| CAS | 552-41-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Ethanol: 33 mg/mL (198.59 mM) DMSO: 60 mg/mL (361.08 mM) H2O: < 1 mg/mL (insoluble or slightly soluble) |
| References | 1. Kong LD, et al. J Ethnopharmacol, 2004, 91(2-3), 351-355. 2. Chou TC, Br J Pharmacol, 2003, 139(6), 1146-1152. 3. Kim SH, et al. Int Immunopharmacol. 2004, 4(2), 279-287. |