| Description | Osteogenic Growth Peptide, OGP acetate is a short, naturally occurring 14-mer growth factor peptide found in serum at μM concentrations. Osteogenic growth peptide OGP is a key factor in the mechanism of the systemic osteogenic response to local bone marrow injury. |
| In vitro | Osteogenic Growth Peptide, OGP调节成骨细胞系的增殖、分化及基质矿化过程。OGP的活性部分，即OGP(10-14)区域，从肽中裂解并与OGP受体结合，激活MAP激酶、Src以及RhoA途径[1]。OGP是一种与组蛋白H4的C末端一致的天然分子，其序列包含一个高度保守的14个氨基酸基序（NH2-ALKRQGRTLYGFGG-OH）。这种肽体从骨髓删减再生过程中的成骨重塑的血液中分离出来。OGP及其C末端五肽OGP(10-14)已被证实能够刺激成骨系细胞的增殖、分化、碱性磷酸酶活性以及基质矿化[2]。 |
| Synonyms | Osteogenic Growth Peptide, OGP acetate(132996-61-3 free base) |
| molecular weight | 1583.82 |
| Molecular formula | C70H114N22O20 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 5 mM |
| References | 1. Moore NM, et al. The use of immobilized osteogenic growth peptide on gradient substrates synthesized via clickchemistry to enhance MC3T3-E1 osteoblast proliferation. Biomaterials. 2010 Mar;31(7):1604-11. |