| Description | Ophiopogonin D is a natural product,and is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation. |
| In vitro | OPHIOPOGONIN D(OP-D) significantly inhibited Ang II induced NF-κB nuclear translocation, IκBα down-regulation and activation of pro-inflammatory cytokines (TNF-α, IL-6 and VCAM-1) by increasing the expression of CYP2J2/EETs and PPARα in HUVECs.?Furthermore, treatment with exogenous 11,12-EET attenuated endothelial inflammation induced by Ang II as evidenced by inhibited NF-κB nuclear translocation, increased IκBα expression and decreased inflammation factor level.?Finally, the activation of NF-κB nuclear translocation induced by Ang II was also markedly suppressed by fenofibrate.?Co-incubation with 6-(2-proparglyloxyphenyl) hexanoic acid (PPOH) and PPARα inhibitor GW6471 before drug treatment abolished the endothelium protective effects of OP-D.?Suggest that OP-D has the endothelial protective effect through activation of CYP2J and increasing EETs, and PPARα involves in this process. |
| Synonyms | 麦冬皂苷 D, 麦冬皂苷D |
| molecular weight | 855.02 |
| Molecular formula | C44H70O16 |
| CAS | 945619-74-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 30 mg/mL (35.09 mM) |
| References | 1. Huang X , Wang Y , Zhang Z , et al. Ophiopogonin D and EETs ameliorate Ang II-induced inflammatory responses via activating PPARα in HUVECs[J]. Biochemical and Biophysical Research Communications, 2017:S0006291X17311166. |