Nicotinamide Riboside Triflate-product

Description	Nicotinamide Riboside Triflate (SRT647 Triflate) is a natural NAD precursor that increases NAD levels, enhances oxidative metabolism and prevents obesity induced by a high-fat diet+, and can be used in studies of muscle atrophy.
In vitro	Nicotinamide Riboside Triflate (1-1000 μM; HEK293T cells) exhibits a concentration-dependent increase in intracellular and mitochondrial NAD+ content in C2C12, Hepa1.6, and HEK293 cells.[1] Nicotinamide Riboside Triflate (0.5 nM; 24 h; HEK293T cells) reduces the acetylation status of Ndufa9 and SOD2.[1] Nicotinamide Riboside Triflate enhances NAD levels to reinstate the antiviral poly(ADP-ribose) polymerase (PARP) functions, bolstering innate immunity against coronaviruses (CoVs), a contributing factor to COVID-19.[3]
In vivo	Nicotinamide Riboside Triflate（400 mg/kg/天；口服；持续16周；10周龄C57Bl/6J小鼠）导致血浆和细胞内NAD+水平在特定组织中的增加。[1]
Synonyms	SRT 647 Triflate, SRT 647, Nicotinamide Riboside, Nicotinamide Ribose, SRT-647, SRT647, SRT647 Triflate, SRT-647 Triflate
molecular weight	404.32
Molecular formula	C12H15F3N2O8S
CAS	445489-49-6
Storage	store at low temperature　\|　Powder: -20°C for 3 years \| In solvent: -80°C for 1 year
References	1. Cantó C, et al. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metab. 2012 Jun 6;15(6):838-47. 2. Gong B, et al. Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models. Neurobiol Aging. 2013 Jun;34(6):1581-8. 3. Heer CD, et al. Coronavirus infection and PARP expression dysregulate the NAD Metabolome: an actionable component of innate immunity. bioRxiv [Preprint]. 2020 Oct 6:2020.04.17.047480. 4. Kourtzidis IA, Dolopikou CF, Tsiftsis AN, Margaritelis NV, Theodorou AA, Zervos IA, Tsantarliotou MP, Veskoukis AS, Vrabas IS, Paschalis V, Kyparos A, Nikolaidis MG. Nicotinamide riboside supplementation dysregulates redox and energy metabolism in rats: Implications for exercise performance. Exp Physiol. 2018 Oct;103(10):1357-1366. doi: 10.1113/EP086964. Epub 2018 Aug 28. PubMed PMID: 30007015.

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Nicotinamide Riboside Triflate

CAS No.: 445489-49-6