| Description | Neocnidilide is an alkyl phthalate derived from Rhizoma Ligustici Chuanxiong with the ability to inhibit the growth of mycotoxin-producing fungi and to kill insects.The LC50 value of Neocnidilide against D. melanogaster larvae was 9.9 μmol/mL.It enhances the skin penetration of benzoic acid.The LC50 value of Neocnidilide against D. melanogaster larvae was 9.9 μmol/mL.It enhances the skin penetration of benzoic acid. |
| In vitro | 在本研究中，作者比较了葡萄牙和意大利自然种群中采集的A. graveolens挥发性分馏物的组成，并评估了其作为抗真菌剂的潜力。通过水蒸气蒸馏获得的挥发性油的组成及其抗真菌活性被报道。这些油通过气相色谱-火焰离子化检测器和气相色谱-质谱法进行了分析，并且与通过超临界CO2分离的挥发性提取物的组成进行了比较。观察到，根据植物的来源和提取方法，提取物中存在化学变异。结果显示主要成分为sedanenolide、Neocnidilide和neophytadiene。使用最小抑制浓度(MIC)和最小致死浓度来评估油对Candida albicans, Candida tropicalis, Candida krusei, Candida guilliermondii, Candida parapsilosis, Cryptococcus neoformans, Trichophyton rubrum, Trichophyton mentagrophytes, T. mentagrophytes var. interdigitale, Trichophyton verrucosum, Microsporum canis, Microsporum gypseum, Epidermophyton floccosum, Aspergillus niger, Aspergillus fumigatus 以及 Aspergillus flavus等真菌的抗真菌活性。富含neophytadiene的意大利油样活性更强，其MIC值为0.04-0.64 μL mL(-1)。 |
| Synonyms | 新蛇床内酯, 新蛇床内酯,新川芎内酯 |
| molecular weight | 194.27 |
| Molecular formula | C12H18O2 |
| CAS | 4567-33-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 45 mg/mL (231.64 mM) |
| References | 1. Marongiu B, et al. Isolation of the volatile fraction from Apium graveolens L. (Apiaceae) by supercritical carbon dioxide extraction and hydrodistillation: chemical composition and antifungal activity.Nat Prod Res. 2013;27(17):1521-7. 2. Jiao XZ, et al. Study of stereoselective synthesis of (+/-)-neocnidilide. J Asian Nat Prod Res. 2003;5(3):165-169. 3. Tsukamoto T, et al. Larvicidal and adulticidal activity of alkylphthalide derivatives from rhizome of Cnidium officinale against Drosophila melanogaster. J Agric Food Chem. 2005;53(14):5549-5553. 4. Xie T, et al. Identification of the metabolites of neocnidilide in rat, monkey and human liver microsomes by liquid chromatography coupled to benchtop Orbitrap mass spectrometry. Biomed Chromatogr. 2023;37(3):e5563. |