| Description | Naringin (Naringoside), a flavanone glycoside, exerts various of pharmacological effects such as blood lipid lowering, antioxidant activity, anticancer activity, and inhibition of cytochrome P450 enzymes. |
| In vivo | Naringin对小鼠的半数致死剂量（Lethal Dose 50）为1650 mg/kg。 |
| Cell experiments | HBZY-1 cells are plated into 96-well plates and pretreated with various concentrations(1, 5, 10, 25, 50, 100 μM) of naringin for 2 h. Then cells are treated with 30 mM glucose for 24 h. The control group is added sterile normal saline in the same volume. After treatment, all the wells are incubated with 20 μL of 5 mg/ml MTT for 4 h at 37°C. Subsequently, 100 μL of DMSO are used to dissolve the formed formazan crystals after removal of the supernatant. The result is recorded at 490 nm on a microplate reader[1]. |
| Synonyms | Naringoside, 柚皮苷 |
| molecular weight | 580.53 |
| Molecular formula | C27H32O14 |
| CAS | 10236-47-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Ethanol: 1 mg/mL (1.7 mM) H2O: < 1 mg/mL (insoluble or slightly soluble) DMSO: 50 mg/mL (86.13 mM) |
| References | 1. Ueng YF, et al. Life Sci, 1999, 65(24), 2591-2602. 2. Schindler R, et al. J Nutr, 2006, 136(6), 1477-1482. 3. Kandhare AD, et al. Fitoterapia, 2012, 83(4), 650-659. 4. Jang S A, Hwang Y H, Kim T, et al. Anti-Osteoporotic and Anti-Adipogenic Effects of the Water Extract of Drynaria roosii Nakaike in Ovariectomized Mice Fed a High-Fat Diet[J]. Molecules. 2019, 24(17): 3051. |