| Description | N-Stearoylsphingosine (Cer(d18:1/18:0)) is an amide compound widely found in eukaryotic organisms that enhances protein phosphatase 2A (PP2A) activity by interfering with the binding of PP2A to PP2A inhibitor 2, leading to dephosphorylation of Akt.N-Stearoylsphingosine is used in prostate cancer research. |
| Synonyms | C(18:0)/C(18:1), Cer(d18:1/18:0), C18 Ceramide (d18:1/18:0), C18 Ceramide |
| molecular weight | 565.95 |
| Molecular formula | C36H71NO3 |
| CAS | 2304-81-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMF: 0.15 mg/mL |
| References | 1. Wang Z, et al. Overexpression of ceramide synthase 1 increases C18-ceramide and leads to lethal autophagy in human glioma. Oncotarget. 2017 Oct 23;8(61):104022-104036. 2. Azizov S, et al. Solvent-resistant microfluidic paper-based analytical device/spray mass spectrometry for quantitative analysis of C18 -ceramide biomarker. J Mass Spectrom. 2021 Apr;56(4):e4611. 3. Oh MJ, et al. Novel phytoceramides containing fatty acids of diverse chain lengths are better than a single C18-ceramide N-stearoyl phytosphingosine to improve the physiological properties of human stratum corneum. Clin Cosmet Investig Dermatol. 2017 Sep 13;10:363-371. |