| Description | N-Methylflindersine (2,2,6-Trimethyl-2H,5H-pyrano[3,2-c]quinolin-5-one) shows strong toxicity towards brine shrimp larvae, with an LD(50) value of 1.39 microg/ml. It also exhibits potent inhibition against N -formylmethionylleucylphenylalanine-induced superoxide production with IC(50) values less than 12 microM. |
| In vitro | 在所隔离的化合物中，N-methylflindersine、(-)-simulanol以及evofolin-C对N-formylmethionylleucylphenylalanine诱导的超氧化物生成显示出强效抑制作用，其IC(50)值均小于12微摩尔[2]。 |
| Synonyms | N-甲基芸香碱, 2,2,6-trimethylpyrano[3,2-c]quinolin-5-one, 2,2,6-Trimethyl-2H,5H-pyrano[3,2-c]quinolin-5-one |
| molecular weight | 241.29 |
| Molecular formula | C15H15NO2 |
| CAS | 50333-13-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 60 mg/ml (248.66 mM) |
| References | 1. Alkaloids from the stem bark of Micromelum falcatum. Chem Pharm Bull (Tokyo). 2009 Jun;57(6):600-2. 2. New phenylpropenoids, bis(1-phenylethyl)phenols, bisquinolinone alkaloid, and anti-inflammatory constituents from Zanthoxylum integrifoliolum. J Nat Prod. 2007 Sep;70(9):1444-8. |