| Description | 1. N-Methylcytisine (Caulophylline)'s nicotinic receptors have high affinity (KD = 5 nM)to nAChR from squid optical ganglia. 2. N-Methylcytisine and N, N-dimethylcytisine did not displace 14C-tubocurarine at a concentration of .1 mM, cytisine was the only effective inhibitor of 14C-tubocurarine specific binding (Ki=7 nM). |
| Target activity | 14C-tubocurarine:7 nM(Ki) |
| Synonyms | N-甲基野靛碱, Caulophylline |
| molecular weight | 204.27 |
| Molecular formula | C12H16N2O |
| CAS | 486-86-2 |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 27.5 mg/mL (134.62 mM) Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble |
| References | 1. Determination of N-methylcytisine in rat plasma by UPLC-MS/MS and its application to pharmacokinetic study[J]. Journal of Chromatography B, 2015, 990:118-124. |