| Description | Myristic acid (Crodacid) , a 14 carbon saturated fatty acid, is a rare molecule in cells and is a substrate of some fatty acid desaturases. This compound has the ability to acylate proteins by covalently binding to the N-terminal glycine residues, in a process called N-terminal myristoylation. Myristoylation of substrate proteins by this fatty acid has the potential to activate and mediate many physiological pathways. Furthermore, saturated fatty acids have been reported to be essential for biological activities of lipopolysaccharides and have demonstrated the ability to induce expression of COX-2 and NFκB (nuclear factor κB) activation. |
| Synonyms | 肉豆蔻酸, Crodacid, Tetradecanoic acid, n-Tetradecanoic acid |
| molecular weight | 228.37 |
| Molecular formula | C14H28O2 |
| CAS | 544-63-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 45 mg/mL (197.04 mM) |
| References | 1. Lee JY,etal.Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4. J Biol Chem. 2001 May 18;276(20):16683-9. 2. Becker LC,etal.Final report of the amended safety assessment of myristic acid and its salts and esters as used in cosmetics.Int J Toxicol. 2010 Jul;29(4 Suppl):162S-86S. 3. Rioux V,etal.Regulation of mammalian desaturases by myristic acid: N-terminal myristoylation and other modulations.Biochim Biophys Acta. 2011 Jan;1811(1):1-8. |