| Description | Mulberroside F shows inhibitory effects on tyrosinase activity and on the melanin formation of melan-a cells, it also exhibits superoxide scavenging activity that is involved in the protection against auto-oxidation, suggests that mulberroside F may be used as a skin whitening agent. |
| In vitro | The current study was carried out to investigate the in vitro effects of an 85% methanol extract of dried Morus alba leaves on melanin biosynthesis, which is closely related to hyperpigmentation. These extracts inhibited the tyrosinase activity that converts dopa to dopachrome in the biosynthetic process of melanin. Mulberroside F (moracin M-6, 3'-di-O-beta-D-glucopyranoside), which was obtained after the bioactivity-guided fractionation of the extracts, showed inhibitory effects on tyrosinase activity and on the melanin formation of melan-a cells. This compound also exhibited superoxide scavenging activity that is involved in the protection against auto-oxidation. But its activity was low and was weaker than of kojic acid. |
| Synonyms | 桑皮苷F, 桑皮苷 F |
| molecular weight | 566.51 |
| Molecular formula | C26H30O14 |
| CAS | 193483-95-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Mulberroside F isolated from the leaves of Morus alba inhibits melanin biosynthesis.Biol Pharm Bull. 2002 Aug;25(8):1045-8. |