| Description | Mulberrofuran Q is an active compound that inhibits the formation of 12-hydroxy-5,8,10-heptadecatrienoic acid (HHT) and thromboxane B2 (cyclooxygenase product) , which protects neuronal cells from hypoxia-glycorrhoea-deficiency (OGD)-induced oxidative stress. |
| In vitro | 研究了来自桑树根皮的各种酚类化合物对大鼠血小板环氧合酶和由(1-14C)花生四烯酸形成的脂氧合酶产物的影响。Kuwanons G 和 H、sanggenon C 以及 Mulberrofuran Q 在10(-3)到10(-4)M的浓度下，能够抑制12-羟基-5,8,10-十七碳三烯酸（HHT）和血栓素B2（环氧合酶产物）的形成；然而，它们增加了12-羟基-5,8,10,14-二十碳四烯酸（12-HETE）（一种脂氧合酶产物）的形成。[2] |
| Synonyms | MulberrofuranQ |
| molecular weight | 592.55 |
| Molecular formula | C34H24O10 |
| CAS | 101383-35-1 |
| Storage | keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Lee HJ, et al. Protection of prenylated flavonoids from Mori Cortex Radicis (Moraceae) against nitric oxide-induced cell death in neuroblastoma SH-SY5Y cells. Arch Pharm Res. 2012 Jan;35(1):163-70. 2. Kimura Y, et al. Effects of phenolic constituents from the mulberry tree on arachidonate metabolism in rat platelets. J Nat Prod. 1986 Jul-Aug;49(4):639-44. |