| Description | Mogroside IIe is a major bioactive component of unripe S. grosvenorii fruit that downregulates the IL-9/IL-9 receptor pathway. |
| In vitro | Mogroside IIE 在胰腺腺泡细胞系AR42J及原代腺泡细胞中，通过剂量和时间依赖的方式降低了由蔗糖素加脂多糖(LPS)引起的胰蛋白酶和组织蛋白酶B的活性[1]。 |
| In vivo | Mogroside IIE treatment decreased the levels of serum lipase and serum amylase in mice injected with cerulein plus LPS without influencing inflammation significantly. A multi-cytokine array revealed that mogroside IIE decreased the level of interleukin 9 (IL-9) in AP mice[1]. |
| molecular weight | 801.01 |
| Molecular formula | C42H72O14 |
| CAS | 88901-38-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 100 mg/mL (124.84 mM) |
| References | 1. Xiao J, et al. Mogroside IIE Inhibits Digestive Enzymes via Suppression of Interleukin 9/Interleukin 9 Receptor Signalling in Acute Pancreatitis. Front Pharmacol. 2020 Jun 10;11:859. 2. Wang L, et al. Cucurbitane glycosides derived from mogroside IIE: structure-taste relationships, antioxidant activity, and acute toxicity. Molecules. 2014 Aug 20;19(8):12676-89. |