| Description | Menadione (Vitamin K3) is a synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo. |
| In vivo | 在AR4-2J细胞中,Menadione（1-20 mM）以剂量和时间依赖的方式抑制细胞增殖。在RALA255-10 g大鼠肝细胞细胞系中,Menadione导致细胞外信号调节激酶和c-Jun N-末端激酶的活化。Menadione Menadione抑制多重耐药的白血病细胞系（IC50=13.5 mM）和原代的白血病细胞系（IC50=18 mM）。100 mM Menadione诱导DNA碎片,引起快速的细胞死亡。在正常胰腺腺泡细胞中,Menadione阻止线粒体的Ca（2+）摄取。 |
| Synonyms | 维生素K3, Vitamin K3, 甲萘醌 |
| molecular weight | 172.18 |
| Molecular formula | C11H8O2 |
| CAS | 58-27-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Ethanol: 32 mg/mL (185.9 mM) DMSO: 55 mg/mL (319.43 mM) |
| References | 1. Gerasimenko JV, et al. J Cell Sci,2002, 115(Pt 3), 485-497. 2. Czaja MJ, et al. Hepatology,2003, 37(6), 1405-1413. 3. Nutter LM, et al. Biochem Pharmacol,1991, 41(9), 1283-1292. 4. Sata N, et al. Free Radic Biol Med,1997, 23(6), 844-850. 5. Laux I, et al. Clin Immunol,2001, 101(3), 335-344. |