| Description | Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist. |
| In vitro | 在人非小细胞肺癌A549和肝癌SMMC-7721细胞中,Matrine抑制细胞生长。其中,在A549细胞中,Matrine通过降低Bcl-2 / Bax蛋白比例,诱导细胞凋亡。 |
| In vivo | 在小鼠中,腹腔注射Matrine的LD50为157 mg/kg. |
| Synonyms | Vegard, 苦参碱, Matridin-15-one, Matrinium, α-Matrine, (+)-Matrine |
| molecular weight | 248.36 |
| Molecular formula | C15H24N2O |
| CAS | 519-02-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Ethanol: 49 mg/mL (197.29 mM) H2O: 11 mg/mL (44.29 mM), Heating is recommended. DMSO: 45 mg/mL (181.18 mM) |
| References | 1. Zhang Y, et al. Cytotechnology, 2009, 59(3), 191-200. 2. Higashiyama K, et al. Biol Pharm Bull, 2005, 28(5), 845-848. 3. Wang XY, et al. Nanfang Yike Daxue Xuebao, 2010, 30(9), 2154-2155. |