| Description | Mansonone E is a topoisomerase II inhibitor with cytotoxic and topo inhibitory potencies. |
| molecular weight | 242.27 |
| Molecular formula | C15H14O3 |
| CAS | 5090-87-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Nishina A, Miura A, Goto M, Terakado K, Sato D, Kimura H, Hirai Y, Sato H, Phay N. Mansonone E from Mansonia gagei Inhibited α-MSH-Induced Melanogenesis in B16 Cells by Inhibiting CREB Expression and Phosphorylation in the PI3K/Akt Pathway. Biol Pharm Bull. 2018;41(5):770-776. doi: 10.1248/bpb.b17-01045. PubMed PMID: 29709914. 2. Mahalapbutr P, Nutho B, Wolschann P, Chavasiri W, Kungwan N, Rungrotmongkol T. Molecular insights into inclusion complexes of mansonone E and H enantiomers with various β-cyclodextrins. J Mol Graph Model. 2018 Jan;79:72-80. doi: 10.1016/j.jmgm.2017.11.006. Epub 2017 Nov 11. PubMed PMID: 29154164. 3. Huang ZH, Zhuo ST, Li CY, Xie HT, Li D, Tan JH, Ou TM, Huang ZS, Gu LQ, Huang SL. Design, synthesis and biological evaluation of novel mansonone E derivatives prepared via CuAAC click chemistry as topoisomerase II inhibitors. Eur J Med Chem. 2013 Oct;68:58-71. doi: 10.1016/j.ejmech.2013.07.011. Epub 2013 Aug 1. PubMed PMID: 23968711. 4. Changwong N, Sabphon C, Ingkaninan K, Sawasdee P. Acetyl- and butyryl-cholinesterase inhibitory activities of mansorins and mansonones. Phytother Res. 2012 Mar;26(3):392-6. doi: 10.1002/ptr.3576. Epub 2011 Jul 21. PubMed PMID: 21780212. |