| Description | Maltotetraose (Fujioligo 450) are potent inhibitors of TNF-α-induced intercellular adhesion molecule-1 (ICAM-1) expression, maltotetraose may be beneficial in the suppression of early atherosclerosis development. |
| In vivo | Maltotetraose reduced PDGF-induced sprout formation by mouse aorta explants and inhibited TNF-α-induced NF-κB activation and ICAM-1 expression in MOVAS-1 cells[1]. |
| Animal experiments | Ex vivo migration of VSMCs was measured by aortic . Mouse thoracic aortas were excised from 8-week-old male Balb/c mice and adipose tissue was removed. The aortas were sectioned into 1-mm–long cross-sections, rinsed with serum-free DMEM, treated with 1 mg/mL collagenenase type II, placed in matrigel-coated wells, covered with 50 uL matrigel, and allowed to gel for more than 30 min at 37℃ in a 5% CO2 atmosphere. The aortic rings were treated with 20 ug/mL MALTOTETRAOSE for 30 min, followed by stimulation with 20 ng/mL PDGF-BB. Aortic ring sprouts were photographed on day 7[1]. |
| Synonyms | Fujioligo 450, Amylotetraose, α-1,4-Tetraglucose, 麦芽四糖 |
| molecular weight | 666.58 |
| Molecular formula | C24H42O21 |
| CAS | 34612-38-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 55 mg/mL (82.51 mM) |
| References | 1. Shin S Y , Jung J Y , Yong Y , et al. Inhibition of PDGF-induced migration and TNFα-induced ICAM-1 expression by maltotetraose from bamboo stem extract (BSE) in mouse vascular smooth muscle cells[J]. Molecular Nutrition & Food Research, 2016, 60(9):2086-2097. 2. Arfelli G , Sartini E . Characterisation of brewpub beer carbohydrates using high performance anion exchange chromatography coupled with pulsed amperometric detection[J]. Food Chemistry, 2014, 142:152-158. |