| Description | Macranthoside B Iis a natural product isolated from Flos Lonicerae, possesses anti-bacterial activity. |
| In vitro | Macranthoside B，一种从金银花 (Lonicera macranthoides) 提取的羽扇豆皂甙，具有体外和体内抗肿瘤活性[1]。 |
| Cell experiments | The anticancer effect of Macranthoside B both in vitro and in vivo using cell proliferation assays and xenograft tumor growth assays. Macranthoside B inhibits the proliferation of various kinds of cancer cells with IC(50) values in the range of 10-20 microM. Moreover, the volume and weight of xenograft tumors in nude mice treated with 5mg/kgMacranthoside B were decreased remarkably compared to those of the vehicle control group. Furthermore, DAPI staining and flow cytometry analysis with Annexin V/PI double staining revealed that more apoptotic cells were observed following Macranthoside B treatment. In addition, degradation of PARP (poly-ADP-ribose polymerase), and activation of the caspase cascade for intrinsic pathways were observed. The expression of Bcl-2 protein decreased and the protein level of Bax increased which leading to an increase of the Bax/Bcl-2 ratio. Macranthoside B exhibited strong anti-tumor effect and mitochondrion-mediated apoptosis induction involved in it[1]. |
| Synonyms | 金银花, 灰毡毛忍冬次皂苷乙 |
| molecular weight | 1075.24 |
| Molecular formula | C53H86O22 |
| CAS | 146100-02-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 10.75 mg/ml(10 mM), Sonication is recommended. |
| References | 1. Wang J , Zhao X Z , Qi Q , et al. Macranthoside B, a hederagenin saponin extracted from Lonicera macranthoides and its anti-tumor activities in vitro and in vivo[J]. Food & Chemical Toxicology, 2009, 47(7):0-1721. 2. Shan Y , Guan F , Zhao X , et al. Macranthoside B induces apoptosis and autophagy via reactive oxygen species accumulation in human ovarian cancer A2780 cells[J]. Nutrition and Cancer, 2016:1-10. |