| Description | Lucidenic acid D2 is a nartural product from G. lucidum AF. |
| In vitro | Here, we showed that triterpenes-rich extract of antlered form of G. lucidum (G. lucidum AF) induces TNFα± production in monocytic THP-1 cells. Furthermore, the extract also synergized with lipopolysaccharide (LPS) to induce TNFα± production in THP-1 cells, suggesting an immunostimulatory role of triterpenes-rich extract of G. lucidum AF. Notably, the extract enhanced LPS-induced phosphorylation of p38 mitogen-activated protein kinase (MAPK), while it suppressed LPS-induced phosphorylation of c-Jun N-terminal kinase (JNK) MAPK. p38 Inhibitor suppressed TNFα± production, while JNK inhibitor enhanced TNFα± production, implying that synergistic effect of the extract may work by modulating p38 and JNK MAPKs. Moreover, we found that the triterpenes-rich extract of G. lucidum AF contains high amounts of lucidenic acids. Lucidenic acid A, Lucidenic acid F and Lucidenic acid D2, which seem to dominantly exist in the extract, were purified from the triterpenes-rich extract. We also identified Lucidenic acid-A and -F as modulators of JNK and p38, respectively. |
| Synonyms | Lucidenic acid D2, 赤芝酸D |
| molecular weight | 514.61 |
| Molecular formula | C29H38O8 |
| CAS | 98665-16-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Lucidenic acids-rich extract from antlered form of Ganoderma lucidum enhances TNFα± induction in THP-1 monocytic cells possibly via its modulation of MAP kinases p38 and JNK.Biochem Biophys Res Commun. 2011 Apr 29;408(1):18-24. |