| Description | Lucidenic acid C has anti-invasive effect, it shows significant inhibitory effects on PMA-induced MMP-9 activity and invasion of HepG(2 )cells. |
| In vitro | Triterpenoid components in the ethanol extract of G. lucidum (YK-02) were separated by means of a semi-preparative RP HPLC. Four major peaks were separated and crystallized from triterpenoids fraction, and were identified as lucidenic acid A, lucidenic acid B, Lucidenic acid C, and lucidenic acid N according to their spectroscopic values of (1)H NMR and MS. Treatment of the lucidenic acids (50 microM) in the presence of 200 nM phorbol 12-myristate 13-acetate (PMA) after 24 h of incubation all resulted in significant inhibitory effects on PMA-induced MMP-9 activity and invasion of HepG(2 )cells. |
| Synonyms | 赤芝酸 C, 赤芝酸C |
| molecular weight | 476.6 |
| Molecular formula | C27H40O7 |
| CAS | 95311-96-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. The anti-invasive effect of lucidenic acids isolated from a new Ganoderma lucidum strain.Mol Nutr Food Res. 2007 Dec;51(12):1472-7. |