| Description | Lindleyin is a novel phytoestrogen and might trigger many of the biological responses evoked by the physiological estrogens. |
| In vitro | One herbal extract, Rhei rhizoma (rhubarb), acts as an agonist to both ERalpha and ERbeta. The phytochemical Lindleyin, a major component of rhubarb, might contribute to this estrogenic activity through ERalpha and ERbeta. 4-Hydroxytamoxifen, an ER antagonist, completely reversed the estrogenic activity of Lindleyin. Lindleyin binds to ERalpha in vitro, as demonstrated using a fluorescent polarization assay. The in vivo effect of rhubarb extract was studied using a vitellogenin assay system in the freshwater fish, Japanese medaka (Oryzias latipes). There were marked increases in serum vitellogenin levels in male medaka exposed to rhubarb extract[1] |
| molecular weight | 478.45 |
| Molecular formula | C23H26O11 |
| CAS | 59282-56-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. The phytochemical lindleyin, isolated from Rhei rhizoma, mediates hormonal effects through estrogen receptors.J Endocrinol. 2002 Nov;175(2):289-96. |