| Description | [Leu5]-Enkephalin (Leu-enkephalin) is an endogenous neuropeptide involved in nociception and an agonist of δ-opioid and μ-opioid receptors (Kis = 4.0 and 3.4 nM, respectively) |
| In vivo | [Leu5]-Enkephalin is found in the brain, the brainstem, and the spinal cord as well as in the peripheral nervous system. Leu-Enkephalin (1 mg/kg) decreases the visceromotor response to colon distension in a mouse model of visceral pain induced by colorectal distension[1]. |
| Synonyms | 亮氨酸脑啡肽, Leucine enkephalin, Leucyl-enkephalin, Leu-enkephalin |
| molecular weight | 555.62 |
| Molecular formula | C28H37N5O7 |
| CAS | 58822-25-6 |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 150 mg/mL (269.97 mM) |
| References | 1. Fabisiak A , Małgorzata Sobocińska, Elżbieta Kamysz, et al. Antinociceptive potency of enkephalins and enkephalinase inhibitors in the mouse model of colorectal distension - proof of concept[J]. Chemical Biology & Drug Design, 2018, 92(1). 2. Meunier J C , Moisand C . Binding of leu5-enkephalin and met5-enkephalin to a particulate fraction from rat cerebrum[J]. Febs Letters, 1977, 77(2):0-213. |