[Leu5]-Enkephalin acetate(58822-25-6 free base)-product

Description	[Leu5]-Enkephalin acetate(58822-25-6 free base) is an endogenous neuropeptide involved in nociception and an agonist of δ-opioid and μ-opioid receptors (Kis = 4.0 and 3.4 nM, respectively)
In vivo	[Leu5]-Enkephalin is found in the brain, the brainstem, and the spinal cord as well as in the peripheral nervous system. Leu-Enkephalin (1 mg/kg) decreases the visceromotor response to colon distension in a mouse model of visceral pain induced by colorectal distension[1].
Target activity	μ opioid receptor:3.4 nM(ki), δ opioid receptor:4.0 nM(ki)
Synonyms	亮氨酸脑啡肽, Leucine enkephalin, Leu-enkephalin, Leucyl-enkephalin
molecular weight	555.63
Molecular formula	C28H37N5O7
Storage	keep away from moisture　\|　Powder: -20°C for 3 years \| In solvent: -80°C for 1 year
References	1. Fabisiak A , Małgorzata Sobocińska, Elżbieta Kamysz, et al. Antinociceptive potency of enkephalins and enkephalinase inhibitors in the mouse model of colorectal distension - proof of concept[J]. Chemical Biology & Drug Design, 2018, 92(1). 2. Meunier J C , Moisand C . Binding of leu5-enkephalin and met5-enkephalin to a particulate fraction from rat cerebrum[J]. Febs Letters, 1977, 77(2):0-213.

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