| Description | Laminaran is a β-1,3-glucan isolated from brown algae, often serving as a typical ligand for Dectin-1. It possesses anti-cancer, immune-modulating, and radiation-protective properties. Laminaran can be catalyzed by glucanase. In in vitro and in vivo experiments, Laminaran has demonstrated anti-tumor activity and may be used for severe cancers. |
| In vitro | Laminarin ( 100-800μg / mL ; 24 h ) had no cytotoxicity to normal epidermal cells JB6 Cl41 and human melanoma cells SK-MEL-28. After 15 hours of treatment, the inhibition percentage of the number of living cells was less than 24 % when the concentration was up to 800μg / mL [ 1 ]. Kelp glycan ( 200μg / mL ; 24-72 hours ) did not induce any growth inhibition of SK-MEL-48 cells after treatment for 28 hours and 24 hours. However, it reduced cell proliferation by 72 % after 36 hours of treatment [ 1 ]. Low concentration of kelp glycan ( 25-50μg / mL ; 24 h ) did not affect the phosphorylation of c-Raf ( Ser259 ), ERK1 / 2 ( Tyr202 / Tyr204 ) and MEK1 / 2 ( Ser 221 ) kinases, as well as the total expression level of the studied proteins. However, it reduced p-MEK and p-ERK2 / 50 at 1 μg / mL [ 1 ]. |
| In vivo | 与PBS-、OVA-和海带蛋白处理的小鼠相比，Laminaran（静脉注射；12.5、25及50 mg/kg；21天）与OVA（50μg）联合使用显著减少了肿瘤质量[2]。 |
| Synonyms | β-1,3-Glucan |
| molecular weight | 521.469 |
| Molecular formula | C18H35NO16 |
| CAS | 9008-22-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 20 mg/mL (38.35 mM), Sonication is recommended. DMSO: < 1mg/ml (insoluble）, Sonication is recommended. |
| References | 1. Malyarenko OS, et al. Laminaran from brown alga Dictyota dichotoma and its sulfated derivative as radioprotectors and radiosensitizers in melanoma therapy.Carbohydr Polym. 2019 Feb 15;206:539-547. 2. Song K, et al. Laminarin promotes anti-cancer immunity by the maturation of dendritic cells.Oncotarget. 2017 Jun 13;8(24):38554-38567. |