| Description | λ-Cyhalothrin (Icon) is a type II synthetic pyrethroid insecticide featuring a high-efficiency, broad-spectrum formula with an α-cyano group. It is employed across various applications for controlling a wide array of pests. As a neurotoxin, λ-Cyhalothrin acts on sodium channels in neuron membranes within the central nervous system. |
| In vitro | The mechanism of λ-Cyhalothrin toxicity produces delay in sodium channel inactivation resulting in persistent depolarization of the nerve membrane. λ-Cyhalothrin produces membrane depolarization, calcium ion infl ux, and neurotransmitter release from rat brain synaptosomes[1]. λ-Cyhalothrin possesses estrogenic properties and is able to function as a xenoestrogen promoting human breast carcinoma cell proliferation in vitro[1].λ-Cyhalothrin has found multiple uses in pest (fleas, cockroaches, flies, and ants) control[1].λ-Cyhalothrin is highly effective against the malaria transmitting species of Anopheles[1]. |
| In vivo | The effect of λ-Cyhalothrin (i.p.) on memory, movement activity, and co-ordination in mice exposed to bilateral clamping of the carotid arteries (BCCA) is investigated. Neither memory nor movement co-ordination are impaired by BCCA or λ-Cyhalothrin. Exploratory locomotor activity is markedly reduced in the BCCA/LCH group. Spontaneous movement activity is significantly reduced in the BCCA/λ-Cyhalothrin group . Exposure to λ-Cyhalothrin coexisting with BCCA decreases motor activity in the mice in 2 subsequent 30-min[1]. |
| Synonyms | lambda-Cyhalothrin, Karate, λ-氯氟氰菊酯, Icon |
| molecular weight | 449.85 |
| Molecular formula | C23H19ClF3NO3 |
| CAS | 91465-08-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 60 mg/mL (133.38 mM), Sonication is recommended. |
| References | 1. Barbara Nieradko-Iwanicka, et al. Effect of Lambda-Cyhalothrin on Memory and Movement in Mice After Transient Incomplete Cerebral Ischemia. Ann Agric Environ Med. 2011;18(1):41-5. 2. Shen X, Xu Z, Zhang X, Yang F. Stable carbon isotope fractionation during the biodegradation of lambda-cyhalothrin. Sci Total Environ. 2015 Nov 1;532:415-9. doi: 10.1016/j.scitotenv.2015.05.045. Epub 2015 Jun 16. PubMed PMID: 26092290. 3. Elhalwagy ME, Abd-Alrahman SH, Nahas AA, Ziada RM, Mohamady AH. Hepatopancreatic intoxication of lambda cyhalothrin insecticide on albino rats. Int J Clin Exp Med. 2015 May 15;8(5):7297-305. eCollection 2015. PubMed PMID: 26221269; PubMed Central PMCID: PMC4509214. 4. Abbas N, Shad SA. Assessment of resistance risk to lambda-cyhalothrin and cross-resistance to four other insecticides in the house fly, Musca domestica L. (Diptera: Muscidae). Parasitol Res. 2015 Jul;114(7):2629-37. doi: 10.1007/s00436-015-4467-2. Epub 2015 Apr 23. PubMed PMID: 25903007. 5. Piner P, Üner N. Neurotoxic effects of lambda-cyhalothrin modulated by piperonyl butoxide in the brain of Oreochromis niloticus. Environ Toxicol. 2014 Nov;29(11):1275-82. doi: 10.1002/tox.21858. Epub 2013 Mar 5. PubMed PMID: 23460558. |