| Description | L-SelenoMethionine (L-(+)-Selenomethionine) is a naturally occurring amino acid. It promotes cell cycle progression and elevates the expression of the antioxidant enzymes thioredoxin reductase, glutathione reductase. |
| In vitro | At 5 μM, L-selenomethionine selectively induces apoptosis in LNCaP prostate cancer cells without affecting non-cancerous cells [1]. c-Myc, cyclin C, proliferating cell nuclear antigen, cyclin-dependent kinase (cdk)1, cdk2, cdk4, cyclin B and cyclin D2 mRNA levels were lower in selenium-deficient cells than in the cells supplemented with 0.25 micromol/L selenomethionine. The phosphorylation state of total cellular protein was higher (57%) in selenium-supplemented cells than in selenium-deficient cells [2]. |
| Synonyms | L-(+)-Selenomethionine, L-硒代蛋氨酸 |
| molecular weight | 196.11 |
| Molecular formula | C5H11NO2Se |
| CAS | 3211-76-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: < 1mg/ml (insoluble）, Sonication is recommended. H2O: 30 mg/mL(152.97 mM), Sonication is recommended. |
| References | 1. Stewart J, et al. Effects of selenomethionine on the gene expression profile of cloned human prostate cancer cells representing a phenotypic continuum of cancer progression. Nutr Cancer. 2008;60(6):826-36. 2. Zeng H. Selenite and selenomethionine promote HL-60 cell cycle progression. J Nutr. 2002 Apr;132(4):674-9. |