| Description | L-Hyoscyamine sulfate (Levsin Sulfate) is the sulfate salt of a belladonna alkaloid derivative and the levorotatory form of racemic atropine isolated from the plants Hyoscyamus niger or Atropa belladonna, which exhibits anticholinergic activity. Hyoscyamine functions as a non-selective, competitive antagonist of muscarinic receptors, thereby inhibiting the parasympathetic activities of acetylcholine on the salivary, bronchial, and sweat glands, as well as the eye, heart, bladder, and gastrointestinal tract. These inhibitory effects cause a decrease in saliva, bronchial mucus, gastric juices, and sweat. Furthermore, its inhibitory action on smooth muscle prevents bladder contraction and decreases gastrointestinal motility. |
| Synonyms | Hyoscyamine sulfate hydrate, Levsin Sulfate, Hyoscyamine Sulphate, 硫酸天仙子胺水合物, L-莨菪碱硫酸盐 |
| molecular weight | 676.8 |
| Molecular formula | C34H48N2O10S |
| CAS | 620-61-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 10 mg/mL (14.77 mM) |
| References | 1. Quan, H., Xia, K., Zeng, J., Chen, M., Lan, X., & Liao, Z. (2016). Overexpression of NtPMT and HnH6H changed hyoscyamine-rich Atropa belladonna to scopolamine-rich varieties. Send To Yao Xue Xue Bao, 51(12), 1913-9. |